Genotoxic effects of dithane M-45 on the bone marrow cells of mice in vivo |
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Authors: | D. C. Gautam L. Kapoor |
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Affiliation: | (1) Department of Biosciences, Himachal Pradesh University, 171005 Shimla, (India) |
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Abstract: | Summary Genotoxic effects of dithane M-45 were studied on the bone marrow cells of male albino mice (Lacca strain) in vivo. Different doses (30 mg, 40 mg and 300 mg/kg b.wt) of dithane M-45 were injected intraperitoneally and their effects were investigated after time intervals of 1, 2, 5 and 10 days. The chromosomal aberrations observed in the bone marrow cells of male mice after treatment with dithane M-45 were fragments, rings, dicentric chromosomes, terminal chromatid deletions, chromatid gaps and breaks. In addition to these chromosomal aberrations, physiological effects such as uneven stretching of chromatin material, end-to-end chromosomal associations, exchange configurations, clumping, stickiness and centromeric associations were also observed. |
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Keywords: | Chromosomal aberrations fungicide dithane M-45 |
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