Natural killer-like activity in human cultured lymphoid cells propagated in the presence of interleukin-2: acquired resistance to prostaglandin E2- or dexamethasone-mediated suppression |
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| Authors: | H Suzuki N Yamashita M Sato M Iwata M Maruyama S Yano |
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| Institution: | (1) First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, School of Medicine, Sugitani, 930-01 Toyama, (Japan) |
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| Abstract: | Summary The cytotoxic activity of human peripheral blood lymphocytes against the natural killer-sensitive target K562 was suppressed both by prostaglandin E2 and dexamethasone. On the other hand, cultured lymphoid cells propagated in the presence of interleukin-2 showed strong cytotoxic reactivity against K562 targets, and were resistant to prostaglandin E2- or dexamethasone-mediated suppression. |
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| Keywords: | Lymphoid cells human cytotoxic activity Killer-sensitive target interleukin-2 prostaglandin E2 dexamathasone |
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