New developments in enzymatic peptide synthesis |
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Authors: | C. -H. Wong K. -T. Wang |
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Affiliation: | 1. Department of Chemistry, Scripps Research Institute, 92037, La Jolla, California, USA 2. Institute of Biological Chemistry, Academia Sinica, Taipei, (Taiwan)
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Abstract: | This review article describes new enzymatic methods developed for the efficient and irreversible synthesis of peptides based on native and modified proteases, and for the synthesis of polypeptides containing D- and/or unnatural amino acids. Potential opportunities for future developments in the field based on new enzymes, tailormade catalytic antibodies, and on the technique of in vitro mutagenesis are also described. |
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