Application of atomic force microscopy to living samples from cells to fresh tissues |
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| Authors: | PeiPei Chen HongTao Dong Long Chen QuanMei Sun Dong Han |
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| Institution: | (1) National Center for Nanoscience and Technology, Beijing, 100190, China;(2) Mangya Public Security Bureau, Haixi Mongolian and Tibetan Autonomous Prefecture of Qinghai Province, 816400 Qinghai, China |
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| Abstract: | Atomic force microscopy is a novel method for imaging and characterization in biomedicine. However, high-resolution imaging
of living samples from cells to tissues still remains a challenge. In this paper, two types of AFM working mode (contact mode
and tapping mode) which are utilized for the imaging of living cells and tissues are discussed. A new magnetic tapping mode
(MAC mode), which is more suitable for living samples, and a novel data collecting system named TREC, are also introduced.
Supported by the National Natural Science Foundation of China (Grant No. 90709054) and National Basic Research Program of
China (Grant Nos. 2005CB724700, 2006CB705600) |
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| Keywords: | atomic force microscopy living cells tissue MAC mode biomechanics |
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