Proteinases in cutaneous wound healing |
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Authors: | M Toriseva V-M Kähäri |
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Institution: | (1) Department of Dermatology, Department of Medical Biochemistry and MediCity Research Laboratory, University of Turku, P.O.B 52, 20521 Turku, Finland;(2) Turku Graduate School of Biomedical Sciences, University of Turku, P.O.B 52, 20521 Turku, Finland |
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Abstract: | Cutaneous wound healing is a complex and highly coordinated process where a number of different cell types participate to
renew the damaged tissue under the strict regulation of soluble and insoluble factors. One of the most versatile processes
involved in wound repair is proteolysis. During cell migration, proteins of extracellular matrix are cleaved, often creating
biologically active cleavage products, and proteolysis of cellular contacts leads to increased cell motility and division.
Moreover, proteases activate various growth factors and other proteases in wound and regulate growth factor signaling by shedding
growth factor receptors on cell surface. Normally, proteolysis is strictly controlled, and changes in protease activity are
associated with alterations in wound closure and scar formation. Here, we present the current view on the role of metalloproteinases
and the plasmin-plasminogen system in normal and aberrant cutaneous wound repair and discuss their role as potential therapeutic
targets for chronic ulcers or fibrotic scars.
Received 07 July 2008; received after revision 11 August 2008; accepted 13 August 2008 |
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Keywords: | " target="_blank"> ADAM ADAMTS fibrosis MMP plasminogen skin wound |
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