Molecular aspects of membrane fission in the secretory pathway |
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Authors: | Corda D Hidalgo Carcedo C Bonazzi M Luini A Spanò S |
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Affiliation: | (1) Department of Cell Biology and Oncology, Istituto di Ricerche Farmacologiche 'Mario Negri', Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Chieti (Italy), Fax + 39 0872 570 412, e-mail: corda@dcbo.negrisud.it, IT |
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Abstract: | Membrane fission is essential in various intracellular dissociative transport steps. The molecular mechanisms by which endocytic vesicles detach from the plasma membrane are being rapidly elucidated. Much less is known about the fission mechanisms operating at Golgi tubular networks; these include the Golgi transport and sorting stations, the trans-Golgi and cis-Golgi networks, where the geometry and physical properties of the membranes differ from those at the cell surface. Here we discuss the lipid and protein machineries that have so far been related to the fission process, with emphasis on those acting in the Golgi complex. Received 10 May 2002; received after revision 20 June 2002; accepted 26 June 2002 RID="*" ID="*"Corresponding author. |
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Keywords: | . CtBP3/BARS Golgi complex membrane traffic acyl-transferase acyl-CoA phosphatidic acid phospholipase D protein kinase PITP. |
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