| 流动注射化学发光同时测定利福平和异烟肼 |
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| 引用本文： | 何月珍.流动注射化学发光同时测定利福平和异烟肼[J].安徽师范大学学报(自然科学版),2011,34(2):150-153. |
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| 作者姓名： | 何月珍 |
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| 作者单位： | 安徽师范大学化学与材料科学学院,安徽芜湖,241000 |
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| 基金项目： | 安徽师范大学青年基金(2008xqn62) |
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| 摘 要： | 提出了一种基于人工神经网络的流动注射化学发光同时测定利福平(RFP)和异烟肼(INH)的新方法:在碱性条件下RFP和INH均可定量还原N-溴代丁二酰亚胺(NBS)产生化学发光,而二者的反应动力学光谱不同.通过测量不同反应时间的化学发光强度,用人工神经网络(ANN)建立校正模型并进行预测可同时测定RFP和INH.相比较已报道的同时测定RFP和INH的方法,本方法具有灵敏度高,简单快速等优点,并已成功地用于药物合剂中RFP和INH的同时测定.
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| 关 键 词： | 流动注射化学发光 人工神经网络 利福平 异烟肼 |
Simultaneous Determination of Rifampicin and Isoniazid by Chemiluminescence with Artificial Neural Network Calibration |
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| HE Yue-zhen.Simultaneous Determination of Rifampicin and Isoniazid by Chemiluminescence with Artificial Neural Network Calibration[J].Journal of Anhui Normal University(Natural Science Edition),2011,34(2):150-153. |
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| Authors: | HE Yue-zhen |
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| Institution: | HE Yue-zhen(College of Chemistry and Material Science,Anhui Normal University,Wuhu 241000,China) |
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| Abstract: | In this paper,a flow chemiluminescence(CL) system with artificial neural network(ANN)calibration is proposed for simultaneous determination of rifampicin(RFP) and isoniazid(INH).This method is based on the different kinetic spectra of the analytes in their CL reaction with alkaline N-bromosuccinimide as oxidant.The CL intensity was measured and recorded at different times during the reaction and all the data were processed by ANN calibration.Compared with reported methods for simultaneous determination of R... |
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| Keywords: | flow chemiluminescence artificial neural network rifampicin isoniazid |
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