The effect of surgery and anesthetic agents on granulocyte-chemiluminescence in whole blood |
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| Authors: | M Heberer A M Zbinden M Ernst M Dürig F Harder |
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| Institution: | (1) Department of Surgery, Department of Anesthesia University of Basel/Kantonsspital, CH-4031 Basel, (Switzerland);(2) Forschungsinstitut Borstel, Parkallee, D-2061 Borstel, (Federal Republic of Germany) |
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| Abstract: | Summary The effect of anesthesia and major abdominal surgery on zymosan-induced chemiluminescence (CL) of neutrophil granulocytes was evaluated. CL was measured in diluted whole blood taken at distinct intervals within the perioperative period. In addition, blood samples from healthy volunteers were supplemented with ether and halothane to investigate the in vitro effect of these agents. The phagocytosis-induced CL was not found to be depressed by anesthesia and surgery. Only at supranarcotic concentrations was CL reduced. Surgery and anesthesia, therefore, do not appear to impair this defense system significantly under the conditions of this investigation. |
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| Keywords: | Chemiluminescence anesthesia surgery abdominal granulocytes perioperative period immunological resistance |
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