A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility |
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Authors: | Reich David Patterson Nick De Jager Philip L McDonald Gavin J Waliszewska Alicja Tandon Arti Lincoln Robin R DeLoa Cari Fruhan Scott A Cabre Philippe Bera Odile Semana Gilbert Kelly M Ann Francis David A Ardlie Kristin Khan Omar Cree Bruce A C Hauser Stephen L Oksenberg Jorge R Hafler David A |
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Institution: | Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. reich@receptor.med.harvard.edu |
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Abstract: | Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis. |
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