Prostaglandin production by human polymorphonuclear leucocytes during phagocytosis in vitro |
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| Authors: | G Tolone L Bonasera M Brai C Tolone |
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| Institution: | (1) Istituto di Patologia Generale dell'Università, Corso Tukory 211, I-90134 Palermo, Italy;(2) Present address: Clinica Pediatrica Università Ia, Napoli, Italy |
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| Abstract: | Summary Human polymorphonuclear leukocytes were found to be able to synthetize and release substantial amounts of PGE2, when stimulated by a phagocytic stimulus such as zymosan particles coated with complement. Hydrocortisone, at a concentration of 10–5 M, which proved to be effective in other biological systems, failed to inhibit phagocytosis and PG release. |
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