Effects of oestrogen and progesterone on rat pineal N-acetyl transferase activity and melatonin production |
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| Authors: | M Wilkinson Josephine Arendt |
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| Institution: | (1) Department of Physiology and Department of Pediatrics and Genetics, University of Geneva Faculty of Medicine, 1211 Geneva 4, Switzerland;(2) Department of Physiology, Royal Free Hospital School of Medicine, 8 Hunter Street, WC1N 1BP London, England |
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| Abstract: | Summary We have extended previous studies on pineal  -receptors to include effects of oestradiol or PMSG treatment in the immature female rat. Neither manipulation has any effect on norepinephrine-induced N-acetyl transferase (NAT) activity in vitro. In the adult ovariectomised rat oestrogen/progesterone priming exerts a small sensitising effect to -stimulation with isoproterenol. Progesterone alone, in vitro, inhibits the release of melatonin from pineals of adult ovariectomised rats.The authors are grateful to J. Bradtke, D. de Ziegler and K.B. Ruf for their help, and to the Swiss National Science Foundation and to the Fonds Emil Barrell for financial support. |
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