Increased vascular prostacyclin activity in rats after endotoxin administration |
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| Authors: | S. Villa G. de Gaetano N. Semeraro |
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| Affiliation: | (1) Laboratory of Cardiovascular Clinical Pharmacology, Istituto di Ricerche Farmacologiche !["lsquo"]("/content/q22j2108236086nw/xlarge8216.gif") Mario Negri!["rsquo"]("/content/q22j2108236086nw/xlarge8217.gif") , Via Eritrea, 62, I-20157 Milan, (Italy);(2) Present address: Istituto di Microbiologia Medica, Università di Bari, Bari, Italy |
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| Abstract: | Summary Endotoxin did not interact in vitro with prostacyclin activity but stimulated its release from vascular tissues when administered in single doses to rats 30 min before testing.Acknowledgments. This work was performed with the partial support of the Italian National Research Council (contract CNR 80-01086-83, Medicina Preventiva-Arteriosclerosi). |
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