L'azione protettiva dell'acido tioctico nell'intossicazione da cianuro di potassio

Summary The protective action of thioctic acid and of its reduced form in acute potassium cyanide poisoning has been studied in comparison with the antitoxic action of other compounds with mercapto or disulfide groups.The results permit the following conclusions: (1) Maximum protective action is given by reduced thioctic acid; (2) thioctic acid and BAL have almost the same activity; (3) cysteine and sodium thiosulfate have a protective activity of a much lower order; (4) panthethine is almost inactive. The authors offer the hypothesis that the greater activity of thioctic acid is due to its possible presence as coenzyme in rhodanese.