FTIR assessment of the secondary structure of proteins in human breast benign and malignant tissues |
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Authors: | Yunxiang Ci Tiyu Gao Jianqiang Dong Xiu Kan Zhenquan Guo |
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Institution: | (1) Department of Chemistry, Peking University, 100871 Beijing, China;(2) Department of Pathology, the First People ’ s Hospital, Beijing Medical University, 100044 Beijing, China;(3) Department of Biology, Peking University, 100871 Beijing, China |
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Abstract: | The compositions of the secondary structures of protein in the human breast normal, hyperplasia, fibroadenoma and invasive
ductal carcinoma tissues have been estimated from the Fourier self deconvolved spectra, the second derivative spectra and
the curve-fitting analysis of the amide I bands in their spectra. Some parameters of the secondary structures of proteins
in these 4 types of tissues are significantly different and located in separate ranges. Fibroadenoma tissue demonstrates the
most remarkable difference in the compositions of α-helical and atypical helical structures. The carcinoma tissue has the
highest ratio of the intermolecular β-sheet content and the intramolecular β-sheet content. This noticeable difference in
the secondary structure may have important implications for analyzing the properties and types of human breast disease. |
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Keywords: | breast tumor tissue benign malignant FTIR protein secondary structure composition |
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