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Close relation between hypothalamic and cardiac norepinephrine during stress and its role in acute myocardial infarction disrhythmias |
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| Authors: | R Martinez-Sierra F Andres-Trelles C Vazquez Herrero |
| Institution: | (1) Departamento de Farmacología, Hospital General y Clinico, Facultad de Medicina, Avda Menendez Pidal, Córdoba, (Spain);(2) Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Madrid, (Spain);(3) Departamento de Cirurgía, Hospital Clinico, Ciudad Universitaria, Madrid, (Spain) |
| Abstract: | Summary The decrease of the norepinephrine levels in hypothalamus and heart caused by stress is prevented by pargyline and imipramine. Such a decrease in spleen and adrenals is not affected. Chlorpromazine and lithium only prevent the norepinephrine decrease in the spleen. The uptake of H3norepinephrine by isolated atria of guinea-pig increases during anoxia; the change to a normal oxygen situation decreases these norepinephrine levels by more than 50%. |
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