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| Three-dimensional recon-struction and analysis of structure characteristics on senile plaques of Alzheimer’s disease | |
| 作者姓名： | YE Wei1 LIU Jianwu2 ZHOU Jiangning3 HU Xian- gyou3 & TANG Xiaowei1 1. Bio-X Laboratory of Physics Department College of Science Zheji- ang University Hangzhou 310027 China 2. Medical School of Zhejiang Province Hangzhou 310000 China 3. College of Life Science University of Science and Technology of China Hefei 230000 China Correspondence should be addressed to Tang Xiaowei |
| 作者单位： | YE Wei1，LIU Jianwu2，ZHOU Jiangning3，HU Xian- gyou3 & TANG Xiaowei1 1. Bio-X Laboratory of Physics Department，College of Science，Zheji- ang University，Hangzhou 310027，China; 2. Medical School of Zhejiang Province，Hangzhou 310000，China; 3. College of Life Science，University of Science and Technology of China，Hefei 230000，China Correspondence should be addressed to Tang Xiaowei |
| 摘 要： | Alzheimer’s disease (AD) is a neurodegenerative dis-order characterized by progressive dementia. The classic neuropathological lesions of Alzheimer’s disease are se-nile plaque (SP) associated with fibrillar and amorphous nonfibrillar amyloid β (Aβ), neurofibrillary tangles (NFTs) and loss of neurons[1,2]. Many studies show that Aβ plays akey role in the pathogenesis of AD, and fibrillar Aβ has relatively high neurotoxic effects[3―5]. Therefore, studying the mechanism of Aβ aggre… |
| 关 键 词： | Alzheimer’s disease senile plaque three-dimensional reconstruction structure characteristics aggregation mechanism. |
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