| 新型99mTcN核混配配合物的制备和小鼠生物分布 |
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| 引用本文： | 楚进锋,李彬,孔德靖,王学斌,张俊波. 新型99mTcN核混配配合物的制备和小鼠生物分布[J]. 北京师范大学学报(自然科学版), 2006, 42(5): 514-517 |
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| 作者姓名： | 楚进锋 李彬 孔德靖 王学斌 张俊波 |
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| 作者单位： | 北京师范大学化学学院,100875北京;北京化工大学理学院,100029,北京;北京师范大学化学学院,100875,北京 |
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| 摘 要： | 经配体交换反应制备了5种新配合物:[99mTcN(PNP5)(CBDTC)] ,[99mTcN(PNP5)(CPEDTC)] ,[99mTcN(PNP5)(CHDTC)] ,[99mTcN(PNP5)(CHPDTC)] 和[99mTcN(PNP5)(MCHDTC)] ,放化纯均大于90%.小鼠生物分布结果显示:5种配合物主要经肾排泄,在血、肝和肺等非靶组织中的清除较快;[99mTcN(PNP5)(CBDTC)] 在5 min时的心肌初始摄取和心与肝比最高,利于快速心肌显像;[99mTcN(PNP5)(MCHDTC)] 的心肌滞留最好,靶与非靶比较高,通过结构修饰提高其心肌摄取,可能发展为一种新型心肌灌注显像剂.
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| 关 键 词： | 99mTcN核混配配合物 心肌灌注显像剂 生物分布 |
| 收稿时间： | 2006-06-15 |
| 修稿时间： | 2006-06-15 |
PREPARATION AND BIODISTRIBUTION IN MICE OF NEW 99mTc-NITRIDE HETEROCOMPLEXES |
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| Chu Jinfeng,Li Bin,Kong Dejing,Wang Xuebin,Zhang Junbo. PREPARATION AND BIODISTRIBUTION IN MICE OF NEW 99mTc-NITRIDE HETEROCOMPLEXES[J]. Journal of Beijing Normal University(Natural Science), 2006, 42(5): 514-517 |
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| Authors: | Chu Jinfeng Li Bin Kong Dejing Wang Xuebin Zhang Junbo |
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| Affiliation: | 1.College of Chemistry, Beijing Normal University, 100875, Beijing, China; 2.College of Science, Beijing University of Chemical Technology, 100029, Beijing, China |
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| Abstract: | Five new()~(99m)Tc-nitride heterocomplexes,[~(99m)TcN(PNP5)(CBDTC)]~( ),[~(99m)TcN(PNP5)(CPEDTC)]~( ),[~(99m)TcN(PNP5)(CHDTC)]~( ),[~(99m)TcN(PNP5)(CHPDTC)]~( )and [~(99m)TcN(PNP5)(MCHDTC)]~( ) are prepared and the preliminary biologic evaluation of them are studied.Their radiochemical purity are over 90% synthesized by ligand exchange reaction.The results of biodistribution in mice show that the activity of blood,liver,lungs and other non-target tissues washes out rapidly and is mainly eliminated through kidneys.Of five complexes,the original myocardial uptake and heart-to-liver ratio at 5 min of [~(99m)TcN(PNP5)(CBDTC)]~( ) are the best in favor of fast cardiac imaging,and [~(99m)TcN(PNP5)(MCHDTC)]~( )possessing the best heart retention and high target-to-non-target ratios could be developed a novel myocardial perfusion imaging agent by structural optimization. |
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| Keywords: | ~(99m)Tc-nitride heterocomplex myocardial perfusion imaging agent biodistribution |
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