| 家兔蓝斑复合核注射P物质对血压和心率的影响 |
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| 引用本文： | 夏保芦,黄丹.家兔蓝斑复合核注射P物质对血压和心率的影响[J].江汉大学学报(自然科学版),2002,30(2):8-10. |
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| 作者姓名： | 夏保芦 黄丹 |
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| 作者单位： | 江汉大学,医学与生命科学学院生理学教研室,湖北,武汉,430056 |
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| 摘 要： | 目的 :探讨P物质在蓝斑复合核对心血管活动的影响。方法 :实验在 35只麻醉、制动、人工呼吸的家兔上进行。结果 :将SP微量注入蓝斑复合核 ,家兔血压明显升高 ,心率加快 ;于蓝斑复合核区内微量注射P物质抗血清 ,使血压降低 ,心率减慢。结论 :SP在蓝斑复合核具有兴奋心血管活动的效应 ,内源性SP可能通过兴奋蓝斑复合核区神经元参与心血管活动的调节
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| 关 键 词： | P物质 P物质抗血清 蓝斑复合核 血压 心率 |
| 文章编号： | 1009-1777(2002)02-0008-03 |
| 修稿时间： | 2002年4月28日 |
The Effects on the Blood Pressure and Heart Rate of Rabbits Induced by Injection of Substance P into their Locus Coeruleus Complex Area |
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| XIA Bao-lu,HUANG Dan.The Effects on the Blood Pressure and Heart Rate of Rabbits Induced by Injection of Substance P into their Locus Coeruleus Complex Area[J].Journal of Jianghan University:Natural Sciences,2002,30(2):8-10. |
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| Authors: | XIA Bao-lu HUANG Dan |
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| Abstract: | Objective: The present study is to explore the effects on cardiovascular activities by the injection of substance P (SP) into locus coeruleus complex area (Lc-Sc). Methods: The experimerts were carried out on the 35 rabbits that were anaesthetized, paralyzed and artificially ventilated. Results: Microinjection of SP into the Lc-Sc of the rahbits induced a marked elevation of their blood pressure and increase in their heart rate. Microinjection of SP antiserum into the Lc-Sc of the rabbits resulted in a marked decrease in blood pressure and heart rate of the rabbits. Conclusion: The resultes indicates that SP can excite cardiovascular activities in the Lc-Sc, the endogenous SP may take part in the regulation of cardiovascular activities by exciting neurons in Lc-Sc area. |
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| Keywords: | substance P substance P antiserum Locus Coeruleus complex Area blood pressure heart rate |
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