| The mutation network for the hemagglutinin gene from the novel influenza A （H1N1 ） virus |
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| 引用本文： | Consortium for Influenza Study at Shanghai Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences.The mutation network for the hemagglutinin gene from the novel influenza A （H1N1 ） virus[J].中国科学通报(英文版),2009,54(13):2168-2170. |
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| 作者姓名： | Consortium for Influenza Study at Shanghai Shanghai Institutes of Biological Sciences Chinese Academy of Sciences |
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| 作者单位： | [1]Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences （Key Laboratory of Computational Biology, CAS-MPG Partner Institute of Computational Biology; Center of Bioinformatics, Key Lab of System Biology; Lab of Synthetic Biology, Institute of Plant Physiology ＆ Ecology; Institute Pasteur）, Shanghai 200031, China [2]School of Life Sciences, Fudan University, Shanghai 200433, China [3]Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 201203, China [4]Cancer Institute, Second Military Medical University, Shanghai 200433, China [5]School of Life Sciences and Technology, South China University of Technology, Guangzhou 510641, China [6]National Engineering Research Center for Antibody Drugs, Shanghai 201203, China [7]Zhujiang Hospital, Southern Medical University, G uangzhou 510282, China [8]Shanghai Municipal Center for Disease Control ＆ Prevention, Shanghai 200336, China [9]Shanghai Center for Bioinformation Technology, Shanghai 200235, China [10]School of Life Sciences and Technology, Tongji University, Shanghai 200092, China [11]National Institute for Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China [12]Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [13]Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China [14]National Engineering Research Center for Biochip Technology, Shanghai Biochip Co. Ltd, Shanghai 201203, China |
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| 摘 要： | A mutation network for the hemagglutinin gene （HA） of the novel type A （H1N1） influenza virus was constructed. Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic. Based on the 658A and 1408T mutations in HA, the viruses evolving into this epidemic were divided into three categories, the Mexico, the transitional and the New York type. The three groups of viruses presented distinctive clustering features in their geographic distributions.
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| 关 键 词： | 流感病毒 血凝素基因 流行性感冒 突变 网络 序列类型 同源性分析 地理分布 |
| 收稿时间： | 2009-05-18 |
| 修稿时间： | 2009-05-22 |
The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus |
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| YunGang He,GuoHui Ding,Chao Bian,Zhong Huang,Ke Lan,Bing Sun,XueCai Wang,YiXue Li,HongYan Wang,XiaoNing Wang,Zhong Yang,Yang Zhong,WeiRong Jin,Hui Xiong,JianXin Dai,YaJun Guo,Hao Wang,XiaoYan Che,Fan Wu,ZhenAn Yuan,Xi Zhang,ZhiWei Cao,XiaoNong Zhou,JiaHai Zhou,ZhiYong Ma,GuangZhi Tong,GuoPing Zhao,Li Jin.The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus[J].Chinese Science Bulletin,2009,54(13):2168-2170. |
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| Authors: | YunGang He GuoHui Ding Chao Bian Zhong Huang Ke Lan Bing Sun XueCai Wang YiXue Li HongYan Wang XiaoNing Wang Zhong Yang Yang Zhong WeiRong Jin Hui Xiong JianXin Dai YaJun Guo Hao Wang XiaoYan Che Fan Wu ZhenAn Yuan Xi Zhang ZhiWei Cao XiaoNong Zhou JiaHai Zhou ZhiYong Ma GuangZhi Tong GuoPing Zhao Li Jin |
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| Institution: | HE YunGang1;DING GuoHui1;BIAN Chao1;HUANG Zhong1;LAN Ke1;SUN Bing1;WANG XueCai1;LI YiXue1;9;WANG HongYan2;WANG XiaoNing2;5;YANG Zhong2;ZHONG Yang2;JIN WeiRong3;14;XIONG Hui3;DAI JianXin4;6;GUO YaJun4;WANG Hao4;CHE XiaoYan7;WU Fan8;YUAN ZhenAn8;ZHANG Xi8;CAO ZhiWei9;10;ZHOU XiaoNong11;ZHOU JiaHai12;MA ZhiYong13;TONG GuangZhi13;ZHAO GuoPing1;2;3;14 & JIN Li1;3 |
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| Abstract: | A mutation network for the hemagglutinin gene (HA) of the novel type A (H1N1) influenza virus was constructed. Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic. Based on the 658A
and 1408T mutations in HA, the viruses evolving into this epidemic were divided into three categories, the Mexico, the transitional and the New York
type. The three groups of viruses presented distinctive clustering features in their geographic distributions. |
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| Keywords: | influenza novel type A (H1N1) virus hemagglutinin gene mutation |
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