The effect of bisamidines of 2,6-diaminoanthraquinone onEntamoeba histolytica infections in rats and hamsters |
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| Authors: | E J Burden S G Carvajal P F Fabio T L Fields Yang-I Lin K C Murdock S A Lang Jr |
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| Institution: | (1) Infectious Disease Research Section, Medical Research Division, American Cyanamid Company, 10965 Pearl River, New York, USA |
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| Abstract: | Summary Bisamidines of 2,6-diaminoanthraquinone have demonstrated potent activity against cecal and hepaticEntamoeba histolytica infections in rats and hamsters, respectively. A number of these compounds compared favorably, in overall drug efficacy, with metronidazole and other standard agents.Acknowledgements. The authors wish to thank Dr B. Jackson and co-workers for the results in the Dominant-Lethal test and N.A. Kuck for the results in the Ames test. |
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