Ⅱ型糖尿病患者体内3-硝基酪氨酸、糖化血红蛋白等生化指标的含量测定及临床意义

目的研究Ⅱ型糖尿病患者血清3-硝基酪氨酸（3-NT）、糖化血红蛋白（HbA1c）等生化指标的含量及临床意义.方法按病例对照研究方法,招募确诊的Ⅱ型糖尿病患者64例,正常人对照病例20例.对入选人群进行人体测量、血生化检测和血清3-NT水平的测定,并分析其临床意义.结果糖尿病组血清中3-NT、体质量指数（BMI）、HbA1c、空腹血糖（FPG）、甘油三酯（TG）、肌酐（Cre）、收缩压、舒张压等指标均明显高于正常对照组（P〈0.05）,单纯糖尿病组、糖尿病并发症组与正常对照组之间进行比较,各指标如3-NT,BMI,HbA1c,FPG,TG,Cre,收缩压,舒张压均具有统计学意义.糖尿病患者血清3-NT与各变量之间的多元线性逐步回归分析结果显示：糖尿病患者血清3-NT的含量受BMI和CHO影响.结论监测糖尿病患者3-NT,HbA1c,BMI及血脂等生化指标十分重要;联合检测3-NT,HbA1c,FPG在糖尿病及并发症的临床诊断及治疗中具有重要意义.

Detection of 3 Nitrotyrosine, Glycosylated Hemoglobin and Other Biochemical Indicators in Serum of Patients with Type II Diabetes and Its Clinical Significance

Objective To study the detection of 3 nitrotyrosine(3-NT),glycosylated hemoglobin(HbA1c)and other biochemical indicators in patients with type II diabetes serum and its clinical significance.Method According to case-control study,40 patients with type Ⅱ diabetes were recruited and 20 cases of healthy volunteers were taken as the control case.The selected subjects were examined in anthropometry and blood biochemistry,such as the level of serum 3-NT,and its clinical significance was analyzed.Results 3-NT in the serum,body mass index(BMI),HbA1c,fasting plasma glucose(FPG),triglyceride(TG),creatinine(Cre),systolic blood pressure and diastolic blood pressure in the diabetic group were significantly higher than those in the normal control group(P<0.05).Compared with those in the normal control group,various indicators in the simple diabetic group and the group of diabetes with complications,such as 3-NT,BMI,HbA1c,FPG,TG,Cre,systolic blood pressure and diastolic blood pressure were significantly different statistically.The multiple linear stepwise regression analysis on the 3-nitrotyrosine and the other variables in the serum of diabetic patients showed that serum 3-nitrotyrosine content of the diabetic patients was influenced by BMI and CHO.Conclusion Mornitoring 3-NT,HbA1c,BMI and blood lipids and other biochemical indicators in patients with diabetes is very important.The simultaneous detection of 3-NT,HbA1c,BMI and blood lipids is of great significance in clinical diagnosis and treatment of diabetes and its complications.