Analgesic effects of 3-carboxysalsolinol alone and in combination with morphine |
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| Authors: | A Marshall M Hirst K Blum |
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| Institution: | (1) Department of Pharmacology, University of Western Ontario, N6A 5C1 London, Ontario, Canada;(2) Department of Pharmacology, University of Texas Health Science Center, 78284 San Antonio, Texas, USA |
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| Abstract: | Summary A biphasic dose-response pattern is generated by the isoquinoline, 3-carboxysalsolinol, in analgesia tests conducted in mice. Carbidopa pretreatment enhances this effect, as well as the morphine-induced analgesic increase by 3-carboxysalsolinol. Naloxone blockade of all of these responses suggests an interaction of the alcohol-based isoquinoline with central opiate receptors.We gratefully acknowledge the receipts of drugs from Merck and Co., West Point, Pennsylvania, and Endo Laboratories, Garden City, New York. A. M. is the recipient of a research scholarship from the Alcoholism and Drug Addiction Research Foundation, Toronto, Ontario, Canada. |
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