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Die Reversibilität der Wirkung von Digitoxin,Strophanthidin und Strophanthidin-3-bromazetat am Papillarmuskel und einer mikrosomalen Na+-K+-aktivierbaren ATPase des Meerschweinchens
Authors:U Fricke  W Klaus
Institution:(1) Pharmakologisches Institut der Universität, 6500 Mainz, Deutschland
Abstract:Summary The reversibility of the inhibitory action of strophanthidin, strophanthidin-3-bromoacetate, and digitoxin on the Na+-K+-ATPase activity (microsomal fraction, guinea-pig brain) was compared with the rate of decline of their positive inotropic effects (papillary muscle, guinea-pig heart) after exposure to drug-free solution. The actions of strophanthidin and digitoxin were easily reduced on both systems. Strophanthidin-3-bromoacetate, however, was found to have an irreversible blocking effect on the transport ATPase, whereas its inotropic action could be rapidly abolished.

Teilergebnisse der Dissertation von U.Fricke, Mainz.
Keywords:
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