| Cyclin D1与p21WAF1在鼻咽癌中的表达 |
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| 引用本文： | 李建萍,张小清,谢明. Cyclin D1与p21WAF1在鼻咽癌中的表达[J]. 湘南学院学报(自然科学版), 2011, 0(3): 1-3 |
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| 作者姓名： | 李建萍 张小清 谢明 |
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| 作者单位： | 湘南学院基础医学课部,湖南郴州423000 |
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| 摘 要： | 目的探讨鼻咽上皮癌变过程中周期蛋白CyclinD1与抑癌基因p21（wild—type p53 activated fragment 1，p21wAF1）蛋白的表达及其意义。方法应用免疫组化方法检测47例鼻咽癌组织、21例癌旁上皮组织和14例正常鼻咽粘膜中Cyclin D1与p21WAF1蛋白表达。结果从鼻咽正常粘膜、癌旁粘膜上皮组织到癌组织，Cyclin D1表达阳性率逐渐增加，并且差异有显著意义（均为P〈0．05）。p21WAF1蛋白在以上组织中阳性率较高，且各组间差异无显著性。结论Cyclin D1、p21WAF1蛋白与鼻咽部上皮细胞恶性增生密切相关，p21wA兀蛋白表达可能与细胞周期调控的反馈机制有关。
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| 关 键 词： | 鼻咽癌 Cyclin D1 p21WAn 表达 |
Expression of Cyclin D1 and p21WFA1 in nasopharyngeal carcinoma |
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| LI Jianping,ZHANG Xiaoqing,XIE Ming. Expression of Cyclin D1 and p21WFA1 in nasopharyngeal carcinoma[J]. , 2011, 0(3): 1-3 |
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| Authors: | LI Jianping ZHANG Xiaoqing XIE Ming |
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| Affiliation: | (Basic Medical Department of Xiangnan University, Chenzhou, Hunan 423000, China) |
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| Abstract: | Objective To study the effects of gene expression Cyclin D1 and p21 WAF1 in nasopharyngeal carcinoma （NPC） tissues. Methods Immunochemicalmethod was used to detect the expression Cyclin D1 and p21 WAF1 protein in 47cases NPC ,21cases of nearby mucosa of the carcinoma , and 14 cases normal nasopharyngeal mucosa. Results The positive rates of Cyclin D1 were increased from normal nasopharyngeal to nearby mueosa and NPC gradually（ P 〈 0.05）. No significant difference of p21wan overexpression were observed. Conclusion Cyclin D1 was found to be closely associated with cell malignant hyperplasia. The overexpression of p21wAF1 gene in NPC is probably of duo to feed back control loop in cell Cyclin. |
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| Keywords: | ：Nasopharyngeal carcinoma Cyclin D1 p21WAF1 Expression |
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