炎症因子在兔动脉粥样硬化易损斑块模型中表达

目的探讨在兔动脉粥样硬化易损斑块模型中的炎症因子C反应蛋白（CRP）及白介素-6（IL-6）的表达特点。方法雄性纯种新西兰大白兔分为对照模型组（n=8）、兔动脉粥样硬化模型组（n=8）和兔易损斑块模型组，采用ELISI法检测血清CRP、IL-6浓度。结果兔动脉粥样硬化斑块模型及易损斑块模型血清浓度CRP（8．68±1．30、13．97±2．85）mg／L均明显高于兔对照组模型（0．80±0．15）mg／L；兔动脉粥样硬化斑块模型及易损斑块模型血清浓度IL-6（180．67±14．93、237．99±41．10）pg/ml均明显高于兔对照组模型（85．65±13．55）pg／ml；兔易损斑块模型组的血清CRP、IL-6浓度（13．97±2．85mg／L、237．99±41．10pg／ml）明显高于兔动脉粥样硬化斑块模型组（8．68±1．30mg／L、180．67±14．93pg／ml）。结论兔动脉粥样硬化模型组及易损斑块模型组血清CRP、IL-6浓度明显高于兔对照组模型组血清CRP、IL-6浓度；兔易损斑块模型组血清CRP、IL-6浓度明显高于兔动脉粥样硬化组。

Expression of inflammatory factors in vulnerable plaque with rabbit atherosclerosis

Objective Study on the expression of feature of C - reactive protein（CRP） and interleukin- 6（IL - 6） on vulnerable plaque with rabbit atherosclerosis. Methods Fifty male pure New Zealand white rabbits were divided into three groups, control group （n = 8）, atherosclerosis group （n = 8） and vulnerable plaque with atherosclerosis group （n = 31 ）, respectively. Then, examining the serum levels of CRP and IL - 6 in each group with enzyme - linked immunosorbent （ELISI）. Results The serum levels of CRP and IL - 6 in atherosclerosis group （8.68 ± 1.30 mg/l, 180.67 ± 14.93 pg/ml） and vulnerable plaque with atherosclerosis group （13.97 ± 2.85 mg/l, 237.99 ± 41.10 pg/ml） were significantly higher than that of control group （0.80 ± 0.15mg/l, 85.65 ± 13.55pg/ml）. Also, compared with atherosclerosis group, the serum levels of CRP and IL- 6 in vulnerable plaque with athemsclerosis group significantly increased. Conclusion It is critical important for CRP and IL -6 to form vulnerable plaque with atherosclerosis.