苦菜提取物对大鼠实验性结肠炎肠组织的保护作用

目的观察苦菜提取物对大鼠结肠炎肠组织的保护作用。方法健康sD大鼠建立大鼠结肠炎模型，灌胃用药2周后，评价大鼠结肠黏膜损伤指数（CMDI），检测结肠组织髓过氧化物酶（MPO）及超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量和细胞肿瘤因子（11NF）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）水平。结果不同剂量苦菜提取物（100，300，500mg／kg）灌胃均能不同程度降低模型大鼠CMDI、MPO活性，减少MDA含量，提高SOD活性，降低TNF、IL-8、IL—10水平，且与用药剂量呈一定量效关系。结论苦菜提取物通过拮抗氧化、免疫调节、损伤修复作用对缓解结肠炎大鼠炎症反应，减轻结肠损伤有一定的疗效。

Protective effects of patrinia villosa on experimental colitis in rats

Objective To observed the protective effect of Patrinia Villosa in rat colitis organization. Methods Rat model of colonitis was established. After treatment with Patrinia Villosa for 2 weeks, the colon mucosal damage index （ CMDI） was evaluated. The activity of myeloperoxidase （MPO）, supemxide dismutase （SOD）, the content of malondialdehyde （MDA） in colon tissues, and the levels of tumor necrosis factor （TNF）, interleukin- 8 （IL- 8） and interleukin - 10 （IL- 10） in serum were examined. Results Patrinia Villosa （100, 300,500 mg/ kg） decreased the values of CMDI, the activity of MPO, the contents of MDA, and the levels of TNF , IL- 8 and IL- 10 , but increased the activity of SOD in a dose - depended manner. Conclusion Patrinia Villosa can effectively relieve the inflammatory reaction and colonic injury in colitis rats by immunoregulation,anti- oxidation and wound repair. There are protective effect of Patrinia Villosa on colitis intestinal tissue.