| 10-对硝基苯氧基癸酸合成工艺的改进 |
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| 引用本文： | 杨建丽,梅乐和,林东强,姚善泾.10-对硝基苯氧基癸酸合成工艺的改进[J].江南大学学报(自然科学版),2006,5(2):207-210. |
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| 作者姓名： | 杨建丽 梅乐和 林东强 姚善泾 |
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| 作者单位： | 浙江大学,材料与化工学院,浙江,杭州,310027 |
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| 基金项目： | 国家自然科学基金项目(20176050)，浙江省科技计划项目(2004C33036)，浙江省回国人员基金项目，教育部留学回国人员基金项目，中德合作DAAD-CSC研究人员项目(PPP) |
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| 摘 要： | 对10-对硝基苯氧基癸酸合成工艺进行了改进.以10-溴代癸酸为原料,与甲醇反应生成10-溴代癸酸甲酯,再与对硝基酚钠反应生成10-对硝基苯氧基癸酸甲酯,最后以固定化脂肪酶水解得到10-对硝基苯氧基癸酸.对中间体的折光率和紫外-可见光谱进行分析,并通过紫外-可见光谱1、H-NMR和13C-NMR以及酶分析应用对最终产物进行确证.结果表明,成功合成出目标化合物,总收率达到71.6%.
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| 关 键 词： | 10-对硝基苯氧基癸酸 10-溴代癸酸甲酯 合成 工艺 |
| 文章编号： | 1670-7147（2006）02-0207-04 |
| 收稿时间： | 2005-01-24 |
| 修稿时间： | 2005-02-28 |
An Improved Synthetic Method of p-Nitrophenoxydecanoic Acid |
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| YANG Jian-li,MEI Le-he,LIN Dong-qiang,YAO Shan-jing.An Improved Synthetic Method of p-Nitrophenoxydecanoic Acid[J].Journal of Southern Yangtze University:Natural Science Edition,2006,5(2):207-210. |
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| Authors: | YANG Jian-li MEI Le-he LIN Dong-qiang YAO Shan-jing |
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| Institution: | College of Materials Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | The synthetic method of p nitrophenoxydecanoic acid was improved in this research.10 bromodecanoic acid was reacted with methanol to produce methyl 10 bromodecanoate which was treated with sodium p nitrophenolate to produce ester,then hydrolyzed with immobilized lipase to obtain p nitrophenoxydecanoic acid.The characteristic of intermediates were analyzed by refractive index and UV IV spectrum.The structure of final product was confirmed by UV VIS,~1H NMR,~(13)C NMR and application to enzyme assay.p Nitrophenoxydecanoic acid was successfully synthesized by using this method with an yield rate of 71.6%. |
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| Keywords: | p-nitrophenoxydecanoic acid methyl 10-bromodecanoate synthesis process |
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