| 两种新型倍半萜类化合物诱导人肝癌细胞SMMC-7721凋亡 |
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| 引用本文： | 陈瑛,孟雪琴,杜宇平,张琪,祝英,王勤.两种新型倍半萜类化合物诱导人肝癌细胞SMMC-7721凋亡[J].兰州大学学报(自然科学版),2008,44(6). |
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| 作者姓名： | 陈瑛 孟雪琴 杜宇平 张琪 祝英 王勤 |
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| 作者单位： | 1. 兰州大学生命科学学院,甘肃,兰州,730000
2. 兰州大学功能有机分子化学国家重点实验室,甘肃,兰州,730000 |
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| 基金项目： | Supported by the Science and Technology Support Project of Gansu Province (0708NKCA124). |
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| 摘 要： | 研究两种从盘花垂头菊中分离出的高含氧甜没药烯型倍半萜（HOBS）化合物对肿瘤细胞的影响．结果显示HOBS能够诱导人肝癌细胞SMMC-7721凋亡．单细胞电泳实验证明HOBS能够以剂量依赖的方式诱导SMMC-7721细胞损伤，流式细胞技术显示HOBS能够以剂量依赖的方式诱导SMMC-7721细胞凋亡，凋亡率达到38．9％，Ci（Ca^2＋）的测定显示HOBS能够诱导，Ci（Ca^2＋）升高，所有的结果证明HOBS能够诱导人肝癌细胞SMMC-7721凋亡．提示这两种化合物有抗人肝癌细胞的SMMC-7721活性，为抗肿瘤药物的设计提供了新的思路．
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| 关 键 词： | 肝癌细胞 SMMC-7721 凋亡 |
Highly oxygenated Bisabolane-type sesquiterpenes induced human hepatoma SMMC-7721 cells apoptosis |
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| CHEN Ying,MENG Xue-qin,DU Yu-ping,ZHANG Qi,ZHU Ying,WANG Qin.Highly oxygenated Bisabolane-type sesquiterpenes induced human hepatoma SMMC-7721 cells apoptosis[J].Journal of Lanzhou University(Natural Science),2008,44(6). |
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| Authors: | CHEN Ying MENG Xue-qin DU Yu-ping ZHANG Qi ZHU Ying WANG Qin |
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| Abstract: | The effects of two novel highly oxygenated bisabolane-type sesquiterpenes (HOBS) isolated from C.Discoideum (Cremanthodium discoidiem) on tumor cells were investigated.The results indicate that HOBS induced DNA damage and apoptosis of SMMC-7721 cells both in a dose-dependent manner as revealed by single cell gel electrophoresis and flow cytometry analyses,and the apoptosis rate was up to 38.9%.Measurement of c_i(Ca~(2+)) showed that HOBS could induce elevation of Ca~(2+).All the results suggest that HOBS co... |
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| Keywords: | HOBS apoptosis SMMC-7721 |
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