| 合成3',4'-表鬼臼毒素邻位醌的新方法 |
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| 引用本文： | 李前荣,罗梅,苏庆德.合成3'',4''-表鬼臼毒素邻位醌的新方法[J].中国科学技术大学学报,2003,33(4):426-430,459. |
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| 作者姓名： | 李前荣 罗梅 苏庆德 |
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| 作者单位： | 中国科学技术大学结构分析重点实验室,安徽,合肥,230026 |
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| 摘 要： | 4'-去甲基表鬼臼毒素(5)与双(三氟乙酸)苯碘(PIFA)或二乙酸苯碘(PIDA)在氯仿或二氯甲烷溶液中室温条件下反应得标题化合物.二甲基缩酮(6)用痕量BF3·Et2O或对-甲基苯磺酸(p-TsOH)处理可以得到相同化合物.本文分析了产物的结构并给出了可能的反应机理.
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| 关 键 词： | 鬼臼毒素 氧化 双（三氟乙酸）苯碘（PIFA） 二乙酸苯碘（PIDA） |
New Methods for Synthesis of 3', 4'-orthoquinone of Epipodophyllotoxin |
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| Abstract.New Methods for Synthesis of 3'', 4''-orthoquinone of Epipodophyllotoxin[J].Journal of University of Science and Technology of China,2003,33(4):426-430,459. |
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| Authors: | Abstract |
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| Abstract: | The title compound was synthesized by the reaction of 4'-demethylepipodophyl lotoxin (5) with phenyliodonium bis (trifluoroacetate) or phenyliodonium diacetate in CHCl3 or CH2Cl2 at room temperature, or by treating the dimethyl ketal (6) with a trace of BF3·Et2 O or p-TsOH. The structural elucidation of the product is described and possi ble mechanisms for its formation are presented. |
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| Keywords: | podophyllotoxin oxidation PIFA PIDA |
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