Interaction of salicylate and noise results in mortality of rats |
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| Authors: | J F Brennan P J Jastreboff |
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| Institution: | (1) University of Massachusetts at Boston, Boston, (USA);(2) Department of Surgery, Section of Otolaryngology, Yale University School of Medicine, 333 Cedar Street, 06510 New Haven, Connecticut, USA |
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| Abstract: | Summary Survival as a function of salicylate dose and the intensity of environmental noise was investigated in 150 adult female pigmented rats. Rats were assigned to groups (n=6/group) defined by combinations of salicylate levels from 0- (saline) to 300 mg/kg, injected subcutaneously, and noise levels from ambient noise to 98 dB SPL, presented daily for 10-h periods for up to 17 days. Mortality occurred in groups exposed to the higher combinations of salicylate and noise. |
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| Keywords: | Salicylate noise mortality weight tinnitus rats |
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