| 基于规则的中性粒细胞参数估计 |
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| 引用本文： | 范一平,蒋慰孙,E. P. Hofer,B. Tibken.基于规则的中性粒细胞参数估计[J].华东理工大学学报(自然科学版),1992(Z1). |
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| 作者姓名： | 范一平 蒋慰孙 E. P. Hofer B. Tibken |
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| 作者单位： | 华东化工学院自动化研究所，华东化工学院自动化研究所，德国乌尔姆大学检测控制与微技术系，德国乌尔姆大学检测控制与微技术系 |
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| 摘 要： | 以控制理论的观点和方法研究了一类中性粒细胞系统的动态数学模型。离子辐射和骨髓移植的效应可解释为模型细胞池初值的变化。中性粒细胞在不同阶段的动态行为表明,这些细胞池初值对功能细胞的效应在时间轴上是相互区别的。应用这些分布特性,提出了基于规则的估计不可测细胞状态的方法。临床的离子辐射和骨髓移植病人数据与仿真结果的比较,验证了本法的有效性。
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| 关 键 词： | 参数估计 仿真 最优化 人工智能 粒细胞 |
Parameter Estimation of Granulocytopoiesis Based on Rules |
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| Fan Yiping.Parameter Estimation of Granulocytopoiesis Based on Rules[J].Journal of East China University of Science and Technology,1992(Z1). |
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| Authors: | Fan Yiping |
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| Abstract: | A mathematical model of granulocytopoiesis is reinvestigated in a view of control science. The effect of ionizing radiation and bone marrow transplantation can be interpreted as the change of initial states of the cell model. The dynamic behaviours of the granulocyte cell at different stages show that dynamic effects of these cells on function cell distinguish themself roughly along the time axis. By using this property, a rule base and a strategy for estimation of unmeasurable cell initial states has been established. Patient data from ionizing radiation and bone marrow transplantation are used to demonstrate the effectiveness of our method. |
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| Keywords: | parameter estimation simulation optimization artificial intellegence granulocytes |
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