| 用细胞电泳技术检测化疗药物电性 |
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| 引用本文： | 梁基选,李庆阁.用细胞电泳技术检测化疗药物电性[J].厦门大学学报(自然科学版),1993,32(4):498-502. |
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| 作者姓名： | 梁基选 李庆阁 |
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| 作者单位： | 厦门大学抗癌研究中心
(梁基选，陈宝(石羡))，厦门大学化学系
(李庆阁)，厦门大学化学系(赵一兵) |
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| 摘 要： | 细胞电泳技术可用于研究氟尿嘧啶(5FU),甲氨喋呤(MTX)和环磷酸胺(CP)等药物的电性,用戊二醛化绵羊红细胞(SRBC)为载体,分别吸附3种化疗药物,均可以导致细胞表面电荷下降致使电泳缓慢率为:5 FU 14.55％,MTX 13.77％,CP 12.21％,这3种药物均带正电荷,此研究对电化学疗法结合化疗治疗恶性肿瘤有参考价值。
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| 关 键 词： | 细胞电泳 电荷 电性 抗癌药 |
Ceil Electrophoretic Determination of Electric Charge of Three Antimetabolites |
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| Liang Jixuan Chen Baoqian Li Qingge Zhao Yibing.Ceil Electrophoretic Determination of Electric Charge of Three Antimetabolites[J].Journal of Xiamen University(Natural Science),1993,32(4):498-502. |
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| Authors: | Liang Jixuan Chen Baoqian Li Qingge Zhao Yibing |
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| Institution: | Liang Jixuan Chen Baoqian Li Qingge Zhao Yibing (Cancer Res. Center) (Dept. of Chem. ) |
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| Abstract: | Using cell electrophoretic technique the electric characteristics of 5-fluo-rouracil(5-FU), methorexate (MTX) and cyclophosphamide (CP) were analyzed, which were bound to the sheep red blood cells (SRBC)treated with glutaraldehyde. The three drugs significantly reduced the net negative electric charges on the surfaces of SRBC and slowed the electrophoretic velocities of SRBC. The electrophoretic slowing rates of 5-FU, MTX and CP were 14. 55%, 13. 77% and 12,21% respectively, indicating that all the three antimetabolites carry positive electric charges. This paper provided the information for the application of electrocbemotherapy to the clinical treatment for carcinomas. |
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| Keywords: | Cell electrophoresis Electric charges Antimetabolites |
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