痛利舒颗粒治疗急性痛风性关节炎的实验研究

通过对痛利舒颗粒的相关药理学研究，评价其对急性痛风性关节炎的治疗作用。建立尿酸钠致急性痛风性关节炎大鼠模型，给予痛利舒颗粒3.24、6.48、12.96 g/kg，考察对踝关节肿胀程度的改善情况；采用热板法测定小鼠痛阈值，给予痛利舒颗粒4.68、9.36、18.72 g/kg，评价其镇痛作用效果；建立巴豆油致小鼠耳廓肿胀模型，给予痛利舒颗粒4.68、9.36、18.72 g/kg，观察其抗炎作用的效果。结果显示,痛利舒颗粒可以改善大鼠踝关节肿胀程度和降低炎症因子TNF α、IL 6含量，提高热板法所测的小鼠的痛阈值，具有一定的镇痛作用，亦对巴豆油所致小鼠耳廓肿胀有一定的抗炎作用。

Experimental study on treating acute gouty arthritis with Tonglishu Granule

Through pharmacological study on Tonglishu Granule, its therapeutic effects on acute gouty arthritis were evaluated. A rat model of acute gouty arthritis induced by sodium urate was established. Tonglishu Granules were given 3.24,6.48 ,12.96 g/kg respectively to investigate the improvement of ankle swelling degree; The pain threshold of mice was determined by hot plate method, and Tonglishu Granules were given 4.68，9.36,18.72 g/kg to evaluate the pain relieving effect; To establish a model for auricle swelling in mice induced by croton oil, Tonglishu Granules were given 4.68, 9.36, 18.72 g/kg to observe its anti inflammatory effect. The results showed that Tonglishu Granule could improve the degree of ankle joint swelling in rats and reduce the levels of inflammatory factors TNF α and IL 6, and improve the pain threshold of mice measured by hot plate method, which had certain analgesic effect. Tonglishu Granule also had certain anti inflammatory effect on croton oil induced ear swelling in mice.