Circadian rhythm of apical Na-channels and Na-transport in rabbit distal colon |
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| Authors: | W Clauss J E Dürr R Krattenmacher H H?rnicke W Van Driessche |
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| Institution: | Institut für Veterin?rphysiologie, Freie Universit?t Berlin, Federal Republic of Germany. |
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| Abstract: | In vivo and in vitro studies showed that electrogenic sodium transport in rabbit distal colon is modulated by aldosterone. It varies in a circadian rhythm; the external synchronizer is the light-dark cycle. The site of regulation was found to be in the apical membrane of colonic epithelial cells, in which the number of conducting sodium-channels is increased by aldosterone. |
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