High altitude influence on the level and turn-over time of cardiac norepinephrine in rats |
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Authors: | M Prioux-Guyonneau J Durand J R Rapin Y Cohen |
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Institution: | (1) Laboratoire de Pharmacodynamie, Faculté de Pharmacie, Rue Jean-Baptiste Clément, F-92290 Chatenay-Malabry, (France) |
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Abstract: | Summary In rats exposed to an altitude, of 2,900 meters the level of endogenous cardiac norepinephrine decreases after the 5th day of exposure. The turner-over time of the amine proceeds in 3 steps which are probablyrelated to periods of stress and adaptation: initial increase, important decrease from the 5th day and return to a normal value from the 12 th day. |
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