Studies on the thyroid in transgenic mice expressing the genes for human and bovine growth hormone |
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| Authors: | A Mayerhofer S Easterly A G Amador J Gher A Bartke J Yun T E Wagner |
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| Institution: | (1) Abteilung Anatomie und Zellbiologie, Universität Ulm, D-7900 Ulm, Federal Republic of Germany;(2) Department of Physiology, School of Medicine, Southern Illinois University, 62901-6512 Carbondale, Illinois, USA;(3) Edison Center, Ohio University, 45701 Athens, Ohio, USA |
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| Abstract: | Summary The thyroid glands of transgenic mice (TM) expressing the genes for human (h) and bovine (b) growth hormone (GH) were studied. The percentages of larger follicles inhGH TM of either sex were significantly greater than in the corresponding normal littermates, and follicles ranging up to 350  m in diameter were present in malehGH TM. In contrast, thyroid follicles were only slightly enlarged in malebGH TM, and were unchanged in femalebGH TM. The serum concentrations of T4 were significantly decreased in malebGH TM and not altered in the other groups. Serum concentrations of T3 were slightly, but significantly increased in femalehGH TM and femalebGH TM, but were unaffected in male TM of either type. Since the principal difference between these foreign GHs in rodents is the additional lactogenic activity of human GH, these results may indicate that the effects of prolactin can influence the development of the thyroid. |
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| Keywords: | Thyroid transgenic mouse human growth hormone thyroid hormones |
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