An immunoreactive peptide in milk contains bombesin-like bioactivity |
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| Authors: | Dr L H Lazarus G Gaudino V Erspamer |
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| Institution: | (1) Peptide Neurochemistry Group, Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, P.O. Box 1233, 27709 Research Triangle Park, North Carolina, USA;(2) Present address: Department of Biomedical Science and Human Oncology, University of Turin, Torino, Italy;(3) Present address: Institute of Medical Pharmacology, University of Rome, Rome, Italy |
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| Abstract: | Summary Parallel in vitro biassays using rat uterus and guinea pig large intestine tissues specific for the bombesin family of peptides, demonstrated that the bombesin-like peptides present in bovine milk can produce a dose-related response similar to bombesin and litorin. The bioactivity of this type of milk peptide appeared to be approximately 20–50% as active as the amphibian peptides. These data support the proposal that a bombesin immunoreactive peptide in milk contains bombesin bioactivity.supported in part by a NATO Fellowship and by the Fogarty International Center of the National Institutes of Health, Bethesda, MD, USA.supported by a grant from the Consiglio Nazionale delle Ricerche |
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| Keywords: | Bombesin litorin bovine milk smooth muscle |
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