| 16s rRNA的保守字和进化树重建 |
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| 引用本文： | 罗辽复,贾孟文.16s rRNA的保守字和进化树重建[J].内蒙古大学学报(自然科学版),2002,33(1):36-42. |
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| 作者姓名： | 罗辽复 贾孟文 |
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| 作者单位： | 内蒙古大学物理学系,理论生物物理研究室,内蒙古,呼和浩特,010021 |
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| 基金项目： | 国家自然科学基金 ( 396 70 1 88,396 0 0 2 3)资助项目~~ |
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| 摘 要： | 据寡核苷（n核苷）频数差定义进化距离，由此构成16s rRNA进化树，当n=7,8时和实验资料符合很好，在寻找出全部进化相关的7－核苷的基础上，本文进一步求得了长度大于7的保守字，它们在一个界别中的诸物种中高度保守，并出现于核糖体序列的基本相同的位置上，这些保守字对于核糖体的早期进化至关重要。
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| 关 键 词： | 保守字 进化树 16srRNA 寡核苷 核糖体 进化树 进化距离 |
| 文章编号： | 1000-1638(2002)01-0036-07 |
| 修稿时间： | 2001年9月18日 |
Conserved Words in 16s Ribosomal RNA Deduced from Evolutionary Tree Reconstruction |
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| Abstract.Conserved Words in 16s Ribosomal RNA Deduced from Evolutionary Tree Reconstruction[J].Acta Scientiarum Naturalium Universitatis Neimongol,2002,33(1):36-42. |
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| Authors: | Abstract |
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| Abstract: | Evolutionary distance is defined by oligonucleotide ( n -bases) frequency difference of two sequences.Phylogenetic tree is reconstructed using a set of 16S (18S) rRNA sequences and the definition of distance.The quality of trees generally improves with increasing n and reaches a plateau of best fit at n =7 or 8.So,the 7-mer or 8-mer frequencies provides a basis to describe rRNA evolution.Then,a group of 7-mers are deduced which are correlate well with evolution.Evolution-related conservative words longer than 7 bases for Bacteria and Archaea in 16S rRNA sequences have been found.They are highly conserved in nearly all species of a kingdom (or a sub-kingdom) and are located on nearly same sites of sequences. The structural meaning of these conservative words is discussed briefly. |
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| Keywords: | Conserved words Evolutionary tree 16s rRNA |
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