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Genetic control by the HLA region of the immune response to factor VIII in hemophilic patients] |
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| Authors: | A Nu?ez-Roldan A Arnaiz-Villena G Nu?ez-Ollero |
| Abstract: | In 10 sibships of haemophilic A patients, every one including 1 haemophilic brother with an antibody to factor VIII and 1 haemophilic brother without antibody, pattern of HLA segregation was analysed. All sibships were HLA haploidentical or different and not HLA identical. This fact suggested a linkage between the major histocompatibility complex and an "Ir" gene to factor VIII. |
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