胃肠道微生物区系在宿主体内共生作用的研究进展

宿主与肠道微生物区系长期共同进化的结果是宿主与细菌间的互利共生.在人的消化系统中拥有成千上万的共生细菌,这些共生细菌对宿主肠道的营养加工、粘膜免疫耐受和一些其它功能具有重要的作用.现行的分子生物学技术和无菌动物模型为研究宿主与共生细菌之间的分子机制提供了前所未有的机遇,有助于我们更深入地理解肠道的共生细菌对人正常生理功能的作用,从而发展新的治疗策略.

Recent Progress of Intestinal Bacterial Symbiosis

One potential outcome of the adaptive coevolution between host and microbiota is the development of commensal or symbiotic relationships, where neither partner is harmed, where benefits are provided. Our digestive system is colonized by a myriad of symbionts and commensals that have important effects on nutrient processing, mucosal immune tolerance and a broad range of other host activities. The current molecular biotechnology and germ free animal model offer an unprecedented opportunity to identify the molecular foundations of these relationships so that we can understand how they contribute to our normal physiology and how they can be exploited to develop new therapeutic strategies.