Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin |
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| Authors: | J D Walton E D Earle H Stähelin A Grieder A Hirota A Suzuki |
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| Institution: | (1) Department of Plant Breeding and Biometry, Cornell University, 14853 Ithaca, New York, USA;(2) Preclinical Research, Sandoz Ltd, CH-4002 Basel, (Switzerland);(3) Department of Agricultural Chemistry, University of Osaka Prefecture, 591 Sakai, (Japan);(4) Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, (Japan) |
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| Abstract: | Summary Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide  -amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2. |
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| Keywords: | Chlamydocin HC-toxin phytotoxin cytostatic agent |
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