Impaired insulin release in aging rats: Metabolic and ionic events |
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| Authors: | M Castro D Pedrosa J I Osuna |
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| Institution: | (1) Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Granada, E-18012 Granada, (Spain);(2) Departamento de Medicina, Facultad de Medicina, Universidad de Granada, E-18012 Granada, (Spain) |
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| Abstract: | We investigated the effect of aging on glucose uptake, glucose-induced O2 consumption, glucose-induced45Ca movements, and calmodulin content to elucidate age-related impairment of glucose-induced insulin release in pancreatic islets of Wistar rats. Intact pancreatic islets from old (24-month-old) rats showed impaired glucose-induced insulin release; glucose uptake and O2 consumption were lower in old than in young (2-month-old) or adult (12-month-old) rats. Moreover,45Ca uptake and calmodulin content were decreased in pancreatic islets from older rats, which explained the impairment in glucose-induced insulin release in aging. No major differences between the 3 age groups in glucose-induced45Ca efflux in pancreatic islets were observed. |
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| Keywords: | Aging glucose uptake calmodulin insulin release pancreatic islets |
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