| 大鼠肝再生相关基因MafF的分子进化研究 |
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| 引用本文： | 范念斯,杨献光. 大鼠肝再生相关基因MafF的分子进化研究[J]. 河南师范大学学报(自然科学版), 2011, 39(1): 162-164,168 |
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| 作者姓名： | 范念斯 杨献光 |
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| 作者单位： | 河南师范大学,生命科学学院,河南,新乡,453007 |
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| 基金项目： | 河南省基础与前沿计划项目，河南师范大学生命科学实验教学中心创新项目 |
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| 摘 要： | Maf家族是碱性亮氨酸拉链(the basic leucine zipper,bZip)转录因子的一个亚群,是v-maf癌蛋白类似物.它可以通过结合不同的底物来调节下游基因的表达.cDNA Microarray结果显示,小Maf家族成员MafF在大鼠部分肝切除后表达水平迅速升高.为了详细研究该基因的特性,我们采用生物信...
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| 关 键 词： | MafF 基因 序列 多态性 系统进化 |
Evolution Analysis of Rat Liver Regeneration Associated Gene MafF |
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| FAN Nian-si,YANG Xian-guang. Evolution Analysis of Rat Liver Regeneration Associated Gene MafF[J]. Journal of Henan Normal University(Natural Science), 2011, 39(1): 162-164,168 |
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| Authors: | FAN Nian-si YANG Xian-guang |
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| Affiliation: | (School of Life Sciences,Henan Normal University,Xinxiang 453007,China) |
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| Abstract: | Maf family proteins are so named because of their structural similarity to the founding member,the oncoprotein v-Maf.The small Maf proteins(MafF,MafG and MafK),as all family members,include a characteristic basic region linked to a leucine zipper(b-Zip) domain which mediates DNA binding and subunit dimerization respectively.cDNA Microarray result displays that MafF mRNA express level rises rapidly after partial hepatectomy(PH) of rat.MafF may be involved in rat liver regeneration.The length polymorphism,stop codon polymorphism,ORF diversity and the high homology of different mammals' MafF genes are analyzed.Then,the polygenetic tree of MafF among different mammalian is established.It is hoped to understand the evolutionary relationship among the mammals' MafF gene and to provide materials for the research to reveal its role during rat liver regeneration. |
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| Keywords: | liver regeneration MafF gene polymorphism system evolution |
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