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Butterfly wing antineoplastic agents |
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| Authors: | G. R. Pettit L. E. Houghton N. H. Rogers R. M. Coomes D. F. Berger P. R. Reucroft J. F. Day J. L. Hartwell H. B. Wood Jr. |
| Affiliation: | (1) Department of Chemistry, Arizona State University, 85281 Tempe, Arizona, USA;(2) Drug Research and Development, National Cancer Institute, National Institutes of Health, 20014 Bethesda, Maryland, USA |
| Abstract: | Zusammenfassung Eine Voruntersuchung der Insektengruppe Lepidoptera auf anti-tumor-aktive Stoffe führte zu einer detaillierten chemischen Prüfung der aus Asien stammenden SchmetterlingeCatopsilia crocale Cramer (Pieridae) undPieris rapae cruavora. Ein bedeutender Teil der Anti-Tumor-Aktivität scheint ihren Ursprung in der chemischen Substanz Isoxanthopterin zu besitzen. The present contribution represents Part XXVII of the series Antineoplastic Agents. For Part XXVI refer toG. R. Pettit, J. F. Day, J. L. Hartwell andH. B. Wood, Nature, Lond.227, 962 (1970). This investigation was supported by Public Health Service Research Grants No. CA-10612-01 to No. CA-10612-04 from the National Cancer Institute, and was presented in part at the American Chemical Society Meeting, Washington, D.C., September 1971. We are also grateful to the National Science Foundation for financial assistance (Grant numbers GB-4939 and GB-6979) used in obtaining the Atlas CH-4B and SM-1B mass spectrometers employed in this study. |
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