Two different gene loci related to the spatial patterning of brain ventricle in vertebrate |
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作者姓名: | LUO Minn LI Bingxi TONG Ying ZHAO Shufang LUO Chen |
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作者单位: | Key Laboratory of Proteomics and Developmental Biology of Education Ministry, Hunan Normal University, Changsha 410081, China |
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基金项目: | Supported by National Natural Science Foundation of China(Grant No.30430370),Program for Changjiang Scholars and Innovative Research Team,Ministry of Education of China(Grant No.IRT0445) |
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摘 要: | Observations on living embryonic brains and the microstructure of brain ventricle of goldfish revealed that there are two brain ventricle phenotypes in gynogenetic haploid embryos. One phenotype is as normal as that of the control inbreeding diploid embryos, which has normal differentiated forebrain, midbrain and hindbrain. Another phenotype is obviously abnormal, the brain patterning is irregular, and no distinct brain ventricle can be observed. The ratio of haploid embryos with normal brain pattern to that with abnormal brain pattern is 1∶3. This ratio indicates that there are two gene loci involved in the spatial patterning of the brain ventricle. Since the possibility that deleterious recessive mutant alleles exist on both of the two gene loci had been excluded in this experiment, the phenotype represented the expressional state rather than the genotype of these two genes. Therefore, the ratio of 1∶3 suggests that the expressing probability for each copy of the two genes is 50%, and the regulatory mechanism of the expression is based on two sets of chromosomes, controlled by the rule of the diploid-dependent regulatory mechanism.
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关 键 词: | goldfish haploid embryo brain ventricle gene. |
Two different gene loci related to the spatial patterning of brain ventricle in vertebrate |
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Authors: | LUO Minn LI Bingxi TONG Ying ZHAO Shufang LUO Chen |
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Institution: | Key Laboratory of Proteomics and Developmental Biology of Education Ministry, Hunan Normal University, Changsha 410081, China |
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Abstract: | Observations on living embryonic brains and the microstructure of brain ventricle of goldfish revealed that there are two brain ventricle phenotypes in gynogenetic haploid embryos. One phenotype is as normal as that of the control inbreeding diploid embryos, which has normal differentiated forebrain, midbrain and hindbrain. Another phenotype is obviously abnormal, the brain patterning is irregular, and no distinct brain ventricle can be observed. The ratio of haploid embryos with normal brain pattern to that with abnormal brain pattern is 1:3. This ratio indicates that there are two gene loci involved in the spatial patterning of the brain ventricle. Since the possibility that deleterious recessive mutant alleles exist on both of the two gene loci had been excluded in this experiment, the phenotype represented the expressional state rather than the genotype of these two genes. Therefore, the ratio of 1:3 suggests that the expressing probability for each copy of the two genes is 50%, and the regulatory mechanism of the expression is based on two sets of chromosomes, controlled by the rule of the diploid-dependent regulatory mechanism. |
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Keywords: | goldfish haploid embryo brain ventricle gene |
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