Inhibition of liver fructose 1,6-bisphosphatase activity by Zn2+: Reversal by imidazole pyruvate |
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| Authors: | P F Han G Y Han T W Cole Jr G S Owen J Johnson Jr |
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| Institution: | (1) Department of Chemistry, Atlanta University, 30314 Atlanta, Georgia, USA;(2) Present address: Department of Chemistry, Morehouse College, Atlanta, Georgia, USA |
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| Abstract: | Summary Imidazole pyruvate was found to be a very potent natural chelating agent in reversing the inhibition of liver fructose 1,6-bisphosphatase activity by Zn2+. This metabolite may play a physiological role in gluconeogenesis.This work was supported by grant RR-8006 from the General Research Branch, Division of Research Resources, NIH, USA. |
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