| 5-氰基-4-氨基-6-甲硫基-2-烷硫基嘧啶化合物的合成与生物活性 |
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| 引用本文： | 余申义,蔡亚仙,李明磊.5-氰基-4-氨基-6-甲硫基-2-烷硫基嘧啶化合物的合成与生物活性[J].北京化工大学学报(自然科学版),2003,30(2):110-112. |
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| 作者姓名： | 余申义 蔡亚仙 李明磊 |
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| 作者单位： | 北京化工大学理学院,北京,100029 |
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| 摘 要： | 以2－氰基－3，3－二甲硫基丙烯腈和S－烷基异硫脲盐为原料，在KF／Al2O3催化下合成了5个标题化合物。所有结构均经IR、^1H-NMR和元素分析确证，并做了初步活性测试。
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| 关 键 词： | 5－氰基－4－氨基－6－甲硫基－2－烷硫基嘧啶 KF／Al2O3 2－氰基－3 3－二甲硫基丙烯腈 S－烷基异硫脲盐 合成 生物活性 氟化钾 催化剂 |
| 修稿时间： | 2002年12月17日 |
Synthesis of 5-cyano-4-amino-6-methylthio-2-alkylthiopyrimidine compounds and their biological activities |
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| YU Shen,yi,CAI Ya,xian,LI Ming,lei.Synthesis of 5-cyano-4-amino-6-methylthio-2-alkylthiopyrimidine compounds and their biological activities[J].Journal of Beijing University of Chemical Technology,2003,30(2):110-112. |
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| Authors: | YU Shen yi CAI Ya xian LI Ming lei |
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| Abstract: | Five 5 cyano 4 amino 6 methylthio 2 alkylthiopyrimidine compounds were synthesized by the reaction of 2 cyano 3,3 dimethylthioacrylonitrile with isothiuronium salts in the presence of KF/Al 2O 3. The structures of these compounds were determined by IR? 1H NMR and elemental analysis and their biological activities were preliminarily evaluated. |
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| Keywords: | KF/Al 2O 3 2 cyno 3 3 dimethylthioacrylonitrile isothiuronium salt synthesis pyrimidine biological activity |
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