| 川芎嗪改善东莨菪碱致大鼠学习记忆障碍研究 |
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| 引用本文： | 祖莹,万梅绪,倪小虎,郭丽萍.川芎嗪改善东莨菪碱致大鼠学习记忆障碍研究[J].哈尔滨商业大学学报(自然科学版),2005,21(6):681-683. |
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| 作者姓名： | 祖莹 万梅绪 倪小虎 郭丽萍 |
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| 作者单位： | 哈尔滨商业大学,药学院,黑龙江,哈尔滨,150076;哈尔滨商业大学,药学院,黑龙江,哈尔滨,150076;哈尔滨商业大学,药学院,黑龙江,哈尔滨,150076;哈尔滨商业大学,药学院,黑龙江,哈尔滨,150076 |
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| 摘 要： | 实验采用三门迷路法研究川芎嗪对东莨菪碱所致大鼠学习记忆障碍的改善作用,并进一步探讨其可能的作用机制.实验结果表明：东莨菪碱能使训练后大鼠的获得性学习记忆能力下降,川芎嗪能改善由东莨菪碱所致大鼠的记忆障碍,统计结果有显著性差异.其作用机制可能是激活胆碱能神经系统的活性,提高脑内乙酰胆碱的含量.
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| 关 键 词： | 三门迷路 学习记忆 东莨菪碱 川芎嗪 |
| 文章编号： | 1672-0946(2005)06-0681-03 |
| 修稿时间： | 2005年7月11日 |
Study on effect of ligustrazine improving scopolamine-induced deficits in learning and memory performance in rats |
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| ZU Ying,WAN Mei-xu,NI Xiao-hu,GUO Li-ping.Study on effect of ligustrazine improving scopolamine-induced deficits in learning and memory performance in rats[J].Journal of Harbin University of Commerce :Natural Sciences Edition,2005,21(6):681-683. |
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| Authors: | ZU Ying WAN Mei-xu NI Xiao-hu GUO Li-ping |
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| Abstract: | Three-Panel maze was used to observe the effect of Ligustrazine to learning and memory of the amnesiac rats which were induced by scopolamine and further discussed the potential mechanism of Ligustrazine.The results showed that scopolamine could reduce the obtainable learning and memory of the practiced rats. Ligustrazine could improve the learning and memory of the amnesiac rats.The results of statistic had significant difference.Perhaps,the mechanism may stimulate the activity of cholinergic nerve system and increase the content of Ach in the brain tissues. |
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| Keywords: | three-panel maze learning and memory scopolamine ligustrazine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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