Regulation of rat renal (Na(+) + K+)-adenosine triphosphatase mRNA levels by corticosterone. |
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| Authors: | L E Klein C S Lo |
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| Affiliation: | Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. |
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| Abstract: | We investigated the mechanisms for glucocorticoid regulation of rat renal NaK-ATPase activity. Our findings suggest that the magnitudes of corticosterone-induced increases in alpha 1 mRNA and beta 1 mRNA levels are similar in the kidney of the adult adrenalectomized rats. The results also suggest that corticosterone restores NaK-ATPase activity in adrenalectomized rats prior to any enhanced sodium delivery. |
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