Suppression of ethanol withdrawal by dopamine |
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| Authors: | K Blum J D Eubanks J E Wallace H A Schwertner |
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| Institution: | (1) Division of Drug Abuse, Department of Pharmacology and Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, 78284 San Antonio, Texas, USA |
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| Abstract: | Summary An ethanol-inhalation technique was used to determine a potential relationship between dopamine and central nervous effects produced by alcohol. Bothl-DOPA and intracranially injected dopamine resulted in attenuation of ethanol-induced withdrawal convulsion scores, whereas, haloperidol, a known dopaminergic blocker was found to significantly increase convulsion scores.We thankB. Wiggins, S. Elston andRaul Marin for technical help. The work was supported gy NIH, Air Force Office of Scientific Research and Pharmaceutical Manufacturers Association Grants. Dr.Blum is also a recipient of the Career Teacher Award, Grant No. 1-T01-D100290-01. |
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